Cannabizetol (CBGD): A new cannabinoid for natural beauty

Cannabizetol (CBGD) is a newly identified cannabis compound showing remarkable antioxidant and anti-inflammatory potential for advanced skincare. This discovery expands the boundaries of cannabis-based cosmetics, offering new possibilities for natural and scientifically backed skin treatments. Laboratory results indicate higher efficacy than both CBD and CBG in skin cell models, positioning it as the next key natural ingredient in anti-aging and restorative formulas.

A discovery expanding the frontiers of cannabis science

The cannabis plant continues to surprise researchers. A team from the University of Milan, in collaboration with the Swiss pharmaceutical company Linnea SA, has identified a new cannabinoid known as cannabizetol (CBGD).
The study, “Cannabizetol, a Novel Cannabinoid: Chemical Synthesis, Anti-inflammatory Activity and Extraction from Cannabis sativa L.”, published in the Journal of Natural Products, reveals that this compound demonstrates strong antioxidant and anti-inflammatory activity on skin cells. This suggests that it may help protect skin from environmental stress while soothing redness and irritation.
Cannabizetol (CBGD) belongs to a rare family called dimeric cannabinoids — molecules formed by linking two cannabinoids into a single structure. While highly technical, this structure could make the compound’s properties more powerful and longer lasting.
For the world of natural skincare and cannabis vapes, this finding opens an exciting door: the development of new plant-derived ingredients with real, scientifically proven skin benefits.

What exactly is Cannabizetol (CBGD)?

Cannabizetol is a compound recently identified in natural extracts of Cannabis sativa. Until now, only two similar molecules were known, making this discovery a new milestone in cannabis research.
Unlike more familiar cannabinoids such as CBD (cannabidiol) or CBG (cannabigerol), this new molecule has a unique double structure. That structural difference may explain its particularly strong antioxidant and soothing activity, even at low concentrations.
In lab tests, cannabizetol (CBGD) was shown to reduce inflammation in skin cells and neutralize free radicals — the main cause of premature aging. Researchers described the results as “significantly superior” compared to other related cannabinoids.

Why this discovery matters to the skincare industry

Our skin faces daily exposure to pollution, UV radiation, stress, and lack of rest. These factors disrupt its natural balance, trigger redness, and accelerate aging.
Over the past few years, skincare has increasingly turned toward natural ingredients that help restore equilibrium. Among these, cannabinoids have proven exceptionally effective — both in cosmetics and in the formulation of cannabis vapes focused on wellness and relaxation.

• CBD is known for its ability to soothe, hydrate, and reduce inflammation.
• CBG has been shown to promote skin regeneration and strengthen its natural barrier.

Now, with the emergence of cannabizetol (CBGD), researchers believe they have found a new generation of cannabis-derived actives capable of going even further in protecting, repairing, and preventing oxidative damage.
Early data suggests that cannabizetol could become a key ingredient for anti-aging, calming, and regenerating formulations, with a focus on sustainability and natural performance.

Effects of Cannabizetol: antioxidant, anti-inflammatory, and natural — A powerful combination

Cannabizetol (CBGD) brings together three attributes that place it at the forefront of cosmetic innovation: it’s antioxidant, anti-inflammatory, and 100% natural. This unique combination of cannabinoid effects makes it an ideal candidate for formulations designed to protect the skin from oxidative stress, soothe irritation, and maintain balance.
In a market increasingly driven by plant-based, science-backed ingredients, cannabizetol (CBGD) stands out as an effective and sustainable alternative for those seeking science-driven, conscious beauty solutions.
The potential of CBGD lies in its dual action:

• Antioxidant: Fights free radicals — the main culprits behind skin aging, dullness, and wrinkles.
• Anti-inflammatory: Helps soothe irritated, sensitive, or reactive skin, reducing redness and discomfort.

In simple terms, this is an ingredient that protects, balances, and enhances the skin from within — without relying on harsh chemicals or synthetic substances.
And because it’s a natural phytocannabinoid, its structure closely resembles the compounds our own bodies produce to keep the skin in balance. This affinity allows it to work gently yet effectively, without disrupting the skin’s natural rhythm.

Cannabizetol: A promising advancement still under study

Despite such encouraging results, experts advise caution and prudence. So far, trials have only been conducted in the laboratory (in vitro), and no studies in humans have been performed yet.
This means that cannabizetol is not yet ready for use in commercial cosmetics, and the effects of this cannabinoid on humans remain unknown. Therefore, further research will be necessary to confirm its efficacy and safety.
The next steps will include:

• Evaluating how CBGD behaves on human skin.
• Analyzing its safety, tolerance, and potential side effects.
• Determining the best way to incorporate it into creams, serums, or oils.

Only then can it be determined whether this cannabinoid could become the future of natural cannabis-based cosmetics. In the meantime, we can continue enjoying the benefits provided by CBD.

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How Cannabizetol could transform the skincare industry

Although it is still too early to see it on store shelves, cannabizetol is already generating excitement in the cosmetics world. Innovative labs and brands are beginning to study how to integrate this type of molecule into their products, aiming for increasingly effective and sustainable formulas.
Some potential future applications of cannabizetol may include:

• Antioxidant serums to protect the skin from pollution and blue light.
• Soothing creams for sensitive or redness-prone skin.
• Regenerative treatments for post-sun exposure or aesthetic procedures.
• Anti-aging formulas combining CBGD with ingredients like hyaluronic acid or peptides.

If research confirms its efficacy, CBGD could become a star ingredient in premium cosmetics, similar to the surge experienced by CBD a few years ago.

Science, sustainability, and innovation: The new era of cannabis cosmetics

Beyond being a novelty, the discovery of cannabizetol reflects something deeper: the evolution of cannabis science toward highly specialized fields such as dermatology and advanced cosmetics.
Cannabis is not just a plant associated with wellness or relaxation; it is a source of natural compounds with enormous biological potential. Its chemical diversity allows the development of more effective, safe, and environmentally friendly active ingredients.
In this context, CBGD symbolizes a new stage: the union of scientific research, sustainability, and conscious beauty.

At GB The Green Brand, we closely follow every advance that broadens the horizons of cannabis applied to wellness. The discovery of cannabizetol demonstrates that continuous research is essential to continue finding natural solutions that improve skin health and care.

Our commitment is to provide reliable information, backed by science, and promote a responsible vision for the use of cannabinoids in cosmetics and health.

Because only through knowledge and transparency can a strong, sustainable, and evidence-based cannabis industry be built.